Immune-mediated hemolytic anemia (IMHA) 🩸 is characterized by immune system dysregulation that leads to destruction of the red blood cells (RBC). IMHA is either primary or secondary to another disorder.
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Saline agglutination test (SAT) is a very easy test to perform and require minimal equipment 💉. A positive result indicates autoagglutination (Clumping) of the red blood cells (RBC) 🩸 caused by anti-RBC antibodies, hence immune-mediated destruction of RBC. A positive result doesn’t differentiate between primary and secondary causes therefore it is important to do a full investigation. Also, IMHA should never be diagnosed solely based on SAT test.